Abstract: Inflammatory bowel disease (IBD) is a collective term encompassing chronic inflammatory conditions of the gastrointestinal tract, primarily comprising ulcerative colitis and Crohn’s disease. Given its rising prevalence and intricate immune mechanisms, IBD has emerged as a focal point in research on digestive system disorders. The trinitrobenzene sulfonic acid (TNBS)-induced model of inflammatory bowel disease is extensively utilized in fundamental studies due to its high induction success rate. This review aims to summarize recent advancements in the mechanisms, modeling techniques, and influencing factors associated with TNBS-induced inflammatory bowel disease models in rodents.

Key words: inflammatory bowel disease, trinitrobenzene sulfonic acid, animal models

摘要： 炎症性肠病是慢性炎症性肠道疾病的一类总称,以溃疡性结肠炎和克罗恩病为两大主要类型,因其发病率逐 年上升,免疫机制复杂,成为消化系相关疾病的一大研究热点。三硝基苯磺酸诱导的炎症性肠病模型,因成模率 高,广泛用于各种基础研究。因此,本文将对近年来三硝基苯磺酸诱导大、小鼠炎症性肠病模型的作用机制、造模 方法及影响因素的研究进展进行综述。

关键词: 炎症性肠病, 三硝基苯磺酸, 动物模型